مرکز توسعه تحقیقات بالینی حضرت علی اصغر (ع)

The purpose of the PENTEC review was to develop models for dose constraints in childhood cancer survivors who received brain radiation therapy (RT) to prevent central nervous system (CNS) morbidities. The study found models for neurocognition, indicating a 5% risk of below-average IQ with specific radiation doses and methotrexate use. There was also a model for brain necrosis risk after certain radiation doses. The review highlights the impact of patient age, RT dose, RT volume, and methotrexate on neurocognitive injury and necrosis risks. However, insufficient data on other CNS morbidity endpoints limited the investigation.

منبع:

https://pubmed.ncbi.nlm.nih.gov/33810950/